rs9886784
A SNP on chromosome 9. Its most notable genotype is A;A: mixed evidence of Alzheimer's disease risk
- Gene
- None listed
- Location
- Chr 91,521,204 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 23%
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AMost notableBadmixed evidence of Alzheimer's disease risk
- A;CNot ratedNo summary available.
- C;CNot ratedaverage
On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 8% A;C 38% C;C 54%
- European ancestry (Utah)A;A 4% A;C 35% C;C 61%
- Han Chinese (Beijing)A;A 4% A;C 36% C;C 61%
- Japanese (Tokyo)A;A <1% A;C 35% C;C 64%
- Yoruba (Nigeria)A;A 17% A;C 55% C;C 28%
- African ancestry (Southwest US)A;A 14% A;C 37% C;C 49%
- Chinese (Denver)A;A <1% A;C 28% C;C 71%
- Gujarati IndianA;A 8% A;C 45% C;C 48%
- Luhya (Kenya)A;A 25% A;C 40% C;C 35%
- Mexican ancestry (Los Angeles)A;A 3% A;C 21% C;C 76%
- Maasai (Kenya)A;A 11% A;C 55% C;C 34%
- TuscanA;A 3% A;C 32% C;C 65%
Related
Conditions, medicines and genes
Notes
From SNPedia
Show notes, about 250 words
rs9886784, a intergenic SNP on chromosome 9, is reported to influence the risk for Alzheimer's disease based on a study of ~1100 Canadian patients. The risk allele is (A); the odds ratio is 3.23 (CI: 1.79 - 5.84). Meta-analysis did NOT show rs9886784 with consistent evidence for association with AD across the investigated data sets: Genetic association analysis testing of 4 GWA signals (rs7101429 [GAB2], rs7019241 [GOLM1], rs10519262 [chromosome 15q], and rs9886784 [chromosome 9p]) using family-based methods. In the combined analyses, only rs7101429 in GAB2 yielded significant evidence of association with the same allele as in the original GWA study (P =.002). The results are in agreement with recent meta-analyses of this and other GAB2 polymorphisms suggesting approximately a 30% decrease in risk for AD among carriers of the minor alleles. None of the other 3 tested loci showed consistent evidence for association with AD across the investigated data sets. Recent insights into the molecular genetics of dementia.
A;A
rs9886784, a intergenic SNP on chromosome 9, is reported to influence the risk for Alzheimer's disease based on a study of ~1100 Canadian patients. The risk allele is (A); the odds ratio is 3.23 (CI: 1.79 - 5.84). PMID 17998437
A;C
a intergenic SNP on chromosome 9, was initially reported to influence the risk for Alzheimer's disease based on a study of ~1100 Canadian patients with risk allele is (A); the odds ratio is 3.23 (CI: 1.79 - 5.84). but has failed to replicated
References
Source and license
Adapted from rs9886784 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.