rs1881747

A SNP in the LOC105378305 gene on chromosome 10. Its most notable genotype is C;C: 1.24x increased risk for LOAD

Gene
LOC105378305
Location
Chr 1052,573,815 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
48%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot rated1.24x increased risk for LOADTypical · 0.036% of people
  2. C;TNot rated1.24x increased risk for LOADTypical · 0.037% of people
  3. T;TNot ratednormalTypical · 0.027% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 36% C;T 37% T;T 27%
  • European ancestry (Utah)C;C 5% C;T 34% T;T 61%
  • Han Chinese (Beijing)C;C 80% C;T 18% T;T 3%
  • Japanese (Tokyo)C;C 82% C;T 17% T;T <1%
  • Yoruba (Nigeria)C;C 24% C;T 49% T;T 27%
  • African ancestry (Southwest US)C;C 18% C;T 49% T;T 33%
  • Chinese (Denver)C;C 84% C;T 16% T;T <1%
  • Gujarati IndianC;C 20% C;T 55% T;T 26%
  • Luhya (Kenya)C;C 33% C;T 49% T;T 18%
  • Mexican ancestry (Los Angeles)C;C 37% C;T 40% T;T 23%
  • Maasai (Kenya)C;C 15% C;T 47% T;T 38%
  • TuscanC;C 1% C;T 35% T;T 64%

Conditions, medicines and genes

Notes

From SNPedia

Notes

Nominally significant association found for this SNP with late-onset Alzheimer's disease (odds ratio 1.24, p=0.011) in a study of ~1000 Caucasian patients, but it would not have withstood statistical correction for multiple testing.

Source and license

Adapted from rs1881747 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.