rs2306402

A SNP in the CTNNA3 gene on chromosome 10. Its most notable genotype is C;C: 1.18x increased risk for late-onset Alzheimer's disease

Gene
CTNNA3
Location
Chr 1067,175,727 (GRCh38)
Highest magnitude
2.1Worth knowing
Tested on
23andMe
Minor allele frequency
33%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBad1.18x increased risk for late-onset Alzheimer's diseaseWorth knowing · 2.146% of people
  2. C;TBad1.18x increased risk for late-onset Alzheimer's diseaseWorth knowing · 2.028% of people
  3. T;TGoodnormalTypical · 0.025% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 46% C;T 28% T;T 25%
  • European ancestry (Utah)C;C 63% C;T 30% T;T 7%
  • Han Chinese (Beijing)C;C 80% C;T 20% T;T 0%
  • Japanese (Tokyo)C;C 91% C;T 9% T;T 0%
  • Yoruba (Nigeria)C;C 1% C;T 18% T;T 80%
  • African ancestry (Southwest US)C;C 11% C;T 26% T;T 63%
  • Chinese (Denver)C;C 84% C;T 16% T;T <1%
  • Gujarati IndianC;C 37% C;T 43% T;T 21%
  • Luhya (Kenya)C;C 3% C;T 34% T;T 64%
  • Mexican ancestry (Los Angeles)C;C 55% C;T 38% T;T 7%
  • Maasai (Kenya)C;C 13% C;T 55% T;T 33%
  • TuscanC;C 73% C;T 23% T;T 5%

Conditions, medicines and genes

Other CTNNA3 SNPs

All CTNNA3 SNPs

Notes

From SNPedia

Notes

Nominally significant association found for this SNP with late-onset Alzheimer's disease (odds ratio 1.18, p=0.024) in a study of ~1000 Caucasian patients, but it would not have withstood statistical correction for multiple testing.

Source and license

Adapted from rs2306402 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.