rs145564988
A SNP in the APP gene on chromosome 21. Its most notable genotype is C;G: Alzheimer's disease (reported)
- Gene
- APP
- Location
- Chr 2125,891,785 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;GMost notableBadAlzheimer's disease (reported)
- G;GGoodcommon/normal
On SNPedia: (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other APP SNPs
- rs63750973A;GConsidered pathogenic for an early-onset form of Alzheimer's diseaseVery important
- rs281865161GA;TCAlzheimer's disease, familialVery important
- rs63749810C;TEarly-onset Alzheimer's diseaseVery important
- rs63749964A;CLikely miscall in 23andMe v4 data; otherwise, Alzheimer's disease pathogenic mutationVery important
- rs63750066C;TEarly-onset Alzheimer's diseaseVery important
- rs63750151C;GAlzheimer's diseaseVery important
- rs63750264C;TAlzheimer's disease mutationVery important
- rs63750399C;TMutation considered pathogenic for Alzheimer diseaseVery important
Notes
From SNPedia
Notes
APP gene mutation, known as c.2148C>G, p.Ile716Met and I716M. Note that this SNP is defined on the plus strand (yet the cDNA is oriented on the minus), and, that there are more common, synonymous, presumably benign variants (c.2148C>A and c.2148C>T) at this location. Reported in AlzForum as pathogenic for Alzheimer's disease based on a 2015 publication .
C;G
see discussion and links at rs145564988
Source and license
Adapted from rs145564988 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.