rs4420638(G;G)

2x+ increased Alzheimer's risk, further genotyping suggested ; increased LDL cholesterol

Magnitude
3.0Important
Repute
Bad
Frequency
0%Average of 10 populations
On SNPedia
rs4420638(G;G)
Gene
APOC1

Frequency

Share of people with G;G in each HapMap population.

  • European ancestry (Utah)0%
  • Han Chinese (Beijing)0%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%
  • African ancestry (Southwest US)0%
  • Chinese (Denver)0%
  • Gujarati Indian0%
  • Mexican ancestry (Los Angeles)0%
  • Maasai (Kenya)0%
  • Tuscan0%

Other genotypes of rs4420638

  1. A;AGoodNormal/Average risk for Alzheimer'sTypical · 0.074% of people
  2. A;GBad~3x increased Alzheimer's risk; 1.4x increased heart disease risk ; increased LDL cholesterolWorth knowing · 2.026% of people

All about rs4420638

Notes

From SNPedia

By itself this SNP is associated with a 2x-3x increased risk of developing late-onset Alzheimer's disease. However suggests that this SNP really only serves as a proxy for the ApoE4 allele which has a larger risk increase. Since feedback from Promethease users suggests that this SNP may not be such an accurate proxy, you may wish to specifically verify your APOE allele status by checking genoset gs216, which checks both rs429358 and rs7412, as well as any other APOE alleles described on the APOE page.

References

Source and license

Adapted from rs4420638(G;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.