rs4420638(A;G)

~3x increased Alzheimer's risk; 1.4x increased heart disease risk ; increased LDL cholesterol

Magnitude
2.0Worth knowing
Repute
Bad
Frequency
26%Average of 10 populations
On SNPedia
rs4420638(A;G)
Gene
APOC1

Frequency

Share of people with A;G in each HapMap population.

  • African ancestry (Southwest US)47%
  • European ancestry (Utah)37%
  • Maasai (Kenya)35%
  • Tuscan26%
  • Han Chinese (Beijing)26%
  • Yoruba (Nigeria)25%
  • Chinese (Denver)19%
  • Mexican ancestry (Los Angeles)17%
  • Japanese (Tokyo)14%
  • Gujarati Indian13%

Other genotypes of rs4420638

  1. A;AGoodNormal/Average risk for Alzheimer'sTypical · 0.074% of people
  2. G;GMost notableBad2x+ increased Alzheimer's risk, further genotyping suggested ; increased LDL cholesterolImportant · 3.00% of people

All about rs4420638

Source and license

Adapted from rs4420638(A;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.