rs61761208
A SNP in the PSEN2 gene on chromosome 1. Its most notable genotype is A;T: Early-onset Alzheimer's mutation (reported)
- Gene
- PSEN2
- Location
- Chr 1226,885,602 (GRCh38)
- Highest magnitude
- 8.0Very important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- A;AGoodcommon/normal
- A;TMost notableBadEarly-onset Alzheimer's mutation (reported)
On SNPedia: (A;A), (A;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other PSEN2 SNPs
- rs28936379A;Gearly-onset Alzheimers diseaseVery important
- rs28936380C;Gearly-onset Alzheimer's diseaseVery important
- rs63749851A;CEarly-onset Alzheimer's diseaseVery important
- rs63750215A;Tearly-onset Alzheimer's diseaseVery important
- rs63749884A;Gearly-onset Alzheimer's disease; penetrance not 100%Very important
- rs63750666C;Tearly-onset Alzheimer's disease; penetrance unclearVery important
- rs200754713A;GFrontotemporal dementia (reported)Very important
- rs367855127C;TPossible early-onset Alzheimer's disease mutation; see discussionVery important
Notes
From SNPedia
Notes
rs61761208, also known as c.421A>T, N141Y or Asn141Tyr, is a mutation in the presenilin 2 PSEN2 gene. The minor allele is reported as pathogenic for early-onset Alzheimer's disease in the AlzForum database, based on a 2014 publication.
A;T
see citation at rs61761208
Source and license
Adapted from rs61761208 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.