rs10868366

A SNP in the GOLM1 gene on chromosome 9. Its most notable genotype is C;C.

Gene
GOLM1
Location
Chr 986,085,145 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
32%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratedNo summary available.Typical · 0.00% of people
  2. G;GNot ratedaverageTypical · 0.043% of people
  3. G;TNot ratedreduced risk for AD?Typical · 0.038% of people
  4. T;TNot ratedreduced risk for AD?Typical · 0.019% of people

On SNPedia: (C;C), (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 0% G;G 43% G;T 38% T;T 19%
  • European ancestry (Utah)C;C 0% G;G 86% G;T 13% T;T <1%
  • Han Chinese (Beijing)C;C 0% G;G 22% G;T 53% T;T 25%
  • Japanese (Tokyo)C;C 0% G;G 20% G;T 50% T;T 31%
  • Yoruba (Nigeria)C;C 0% G;G 10% G;T 45% T;T 45%
  • African ancestry (Southwest US)C;C 0% G;G 35% G;T 49% T;T 16%
  • Chinese (Denver)C;C 0% G;G 27% G;T 43% T;T 29%
  • Gujarati IndianC;C 0% G;G 55% G;T 37% T;T 8%
  • Luhya (Kenya)C;C 0% G;G 23% G;T 50% T;T 28%
  • Mexican ancestry (Los Angeles)C;C 0% G;G 77% G;T 21% T;T 2%
  • Maasai (Kenya)C;C 0% G;G 39% G;T 43% T;T 19%
  • TuscanC;C 0% G;G 79% G;T 20% T;T 1%

Conditions, medicines and genes

Other GOLM1 SNPs

All GOLM1 SNPs

Notes

From SNPedia

Notes

rs10868366, a SNP in the GOLM1 gene, is associated with reduced risk for Alzheimer's disease in a study of ~1100 Canadian patients. The protective allele appears to be rs10868366(T), giving an odds ratio of 0.55 (CI: 0.40 - 0.75). GOLPH2 gene markers are not associated with Alzheimer's disease in a sample of the Spanish population. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. Association studies of 19 candidate SNPs with sporadic Alzheimer's disease in the North Chinese Han population.

Source and license

Adapted from rs10868366 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.