rs10553596
A SNP in the CASP7 gene on chromosome 10. Its most notable genotype is TT;TT: common/normal
- Gene
- CASP7
- Location
- Chr 10113,679,882 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (TT;TT). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Notes
From SNPedia
Notes
rs10553596 represents a fairly common variant in the CASP7 gene on chromosome 10, consisting of a deletion of two bases (TT). Roughly 25% of any population carry at least one rs10553596(-) alleles, with somewhat higher frequencies in African populations. An intriguing - though preliminary - report indicates that ApoE4 homozygotes, who are at relatively high risk for late-onset Alzheimer's disease, have their risk reduced (by about half) if they carry at least one rs10553596 minor allele, although it is also possible that the variant delays the age of onset (rather than protects against the disease). The protective effect was not observed for ApoE4 heterozygotes.
Source and license
Adapted from rs10553596 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.