rs10519262

A SNP in the ATP8B4 gene on chromosome 15. Its most notable genotype is A;A: >1.9x risk for AD

Gene
ATP8B4
Location
Chr 1550,140,297 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
24%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad>1.9x risk for ADTypical · 0.08% of people
  2. A;GBad1.9x risk for ADTypical · 0.033% of people
  3. G;GGoodaverageTypical · 0.059% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 8% A;G 33% G;G 59%
  • European ancestry (Utah)A;A 4% A;G 45% G;G 52%
  • Han Chinese (Beijing)A;A 15% A;G 51% G;G 34%
  • Japanese (Tokyo)A;A 19% A;G 48% G;G 34%
  • Yoruba (Nigeria)A;A 0% A;G 11% G;G 89%
  • African ancestry (Southwest US)A;A 0% A;G 9% G;G 91%
  • Chinese (Denver)A;A 25% A;G 42% G;G 33%
  • Gujarati IndianA;A 10% A;G 50% G;G 41%
  • Luhya (Kenya)A;A 0% A;G 5% G;G 96%
  • Mexican ancestry (Los Angeles)A;A 7% A;G 40% G;G 53%
  • Maasai (Kenya)A;A 2% A;G 17% G;G 81%
  • TuscanA;A 7% A;G 45% G;G 48%

Conditions, medicines and genes

Other ATP8B4 SNPs

All ATP8B4 SNPs

Notes

From SNPedia

Notes

rs10519262, a intergenic SNP on chromosome 15, is reported to influence the risk for Alzheimer's disease based on a study of ~1100 Canadian patients. The risk allele is (A); the odds ratio is 1.89 (CI: 1.46 - 2.45).

Source and license

Adapted from rs10519262 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.