rs55687265

A SNP in the ATP8B4 gene on chromosome 15. Its most notable genotype is C;C: risk factor for systemic sclerosis

Gene
ATP8B4
Location
Chr 1549,934,162 (GRCh38)
Highest magnitude
3.0Important
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadrisk factor for systemic sclerosisImportant · 3.0
  2. C;GBadrisk factor for systemic sclerosisWorth knowing · 2.2
  3. G;GGoodcommon/normalTypical · 0.0

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other ATP8B4 SNPs

All ATP8B4 SNPs

Notes

From SNPedia

Notes

rs55687265, also known as c.1308C>G, p.Phe43Leu and F436L, is a rare variant in the ATP8B4 gene on chromosome 15. Exome sequencing followed by a replication cohort study and then a meta-analysis determined that the rs55687265(C) allele, as oriented in dbSNP, is associated with higher risk for systemic sclerosis (SSc; meta-analysis odds ratio 2.5, p = 1.92 x 10e-7).

C;C

see discussion at rs55687265

C;G

see discussion at rs55687265

Source and license

Adapted from rs55687265 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.