rs149307620
A SNP in the NOTCH3 gene on chromosome 19. Its most notable genotype is C;T: Alzheimer's disease, late-onset (possible/predicted)
- Gene
- NOTCH3
- Location
- Chr 1915,191,610 (GRCh38)
- Highest magnitude
- 6.0Very important
- Tested on
- Not on consumer chips
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CGoodcommon/normal
- C;TMost notableBadAlzheimer's disease, late-onset (possible/predicted)
On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other NOTCH3 SNPs
- rs28933696A;GCerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukocenphalopathy, type 1 (CADASIL)Very important
- rs28933697A;GCerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukocenphalopathy, type 1 (CADASIL)Very important
- rs28933698A;GCerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukocenphalopathy, type 1 (CADASIL)Very important
- rs28937321A;CCerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukocenphalopathy, type 1 (CADASIL)Very important
- rs137852641A;GCerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukocenphalopathy, type 1 (CADASIL)Very important
- rs267606915A;TCerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukocenphalopathy, type 1 (CADASIL)Very important
- rs864621964C;TCerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukocenphalopathy, type 1 (CADASIL)Very important
- rs864621966A;CCerebral arteriopathy, autosomal dominant, with subcortical infarcts and leukocenphalopathy, type 1 (CADASIL)Very important
Notes
From SNPedia
Notes
aka p.A284T Ten of about 5,600+ patients with late-onset Alzheimer's disease carried a rs149307620(T) allele, and although numbers are a bit low for a definitive conclusion, the authors of a 2019 publication report this is likely to be a causative mutation with full penetrance.
C;T
see text on main rs-page
Source and license
Adapted from rs149307620 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.