rs2273647

A SNP in the PPP4R3A gene on chromosome 14. Its most notable genotype is C;T: Some protective effect against Alzheimer's by preventing brain glucose decline

Gene
PPP4R3A
Location
Chr 1491,461,942 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
Not on consumer chips

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CBadMost people have this genotype; but the rarer genotype may reduce Alzheimer's riskMinor · 1.074% of people
  2. C;TMost notableGoodSome protective effect against Alzheimer's by preventing brain glucose declineWorth knowing · 2.022% of people

On SNPedia: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 74% C;T 22%
  • European ancestry (Utah)C;C 42% C;T 43%
  • Han Chinese (Beijing)C;C 93% C;T 7%
  • Japanese (Tokyo)C;C 90% C;T 10%
  • Yoruba (Nigeria)C;C 85% C;T 14%
  • African ancestry (Southwest US)C;C 72% C;T 28%
  • Chinese (Denver)C;C 90% C;T 9%
  • Gujarati IndianC;C 59% C;T 35%
  • Luhya (Kenya)C;C 83% C;T 16%
  • Mexican ancestry (Los Angeles)C;C 83% C;T 17%
  • Maasai (Kenya)C;C 81% C;T 19%
  • TuscanC;C 41% C;T 48%

Conditions, medicines and genes

Notes

From SNPedia

Notes

The T allele of rs2273647 in the PPP4R3A gene was found to reduce glucose decline, and in an independent data set, was shown to have some protective effect against the risk of converting from MCI to Alzheimer's disease (p = 0.038) and to protect against cognitive decline in those with AD (p = 3.41 × 10-15 ). The number of patients analyzed in this study is not stated in the abstract and may not be large.

C;C

see rs2273647

C;T

see rs2273647

Source and license

Adapted from rs2273647 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.