rs911541

A SNP in the ENTPD7 gene on chromosome 10. Its most notable genotype is A;A: normal

Gene
ENTPD7
Location
Chr 1099,673,635 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, FamilyTreeDNA
Minor allele frequency
19%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableGoodnormalTypical · 0.067% of people
  2. A;GBad1.58x increased risk of Alzheimer'sTypical · 0.031% of people
  3. G;GBad1.48x increased risk of Alzheimer'sTypical · 0.03% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 67% A;G 31% G;G 3%
  • European ancestry (Utah)A;A 81% A;G 20% G;G 0%
  • Han Chinese (Beijing)A;A 62% A;G 35% G;G 3%
  • Japanese (Tokyo)A;A 65% A;G 29% G;G 6%
  • Yoruba (Nigeria)A;A 50% A;G 44% G;G 7%
  • African ancestry (Southwest US)A;A 51% A;G 47% G;G 2%
  • Chinese (Denver)A;A 65% A;G 29% G;G 6%
  • Gujarati IndianA;A 80% A;G 20% G;G 0%
  • Luhya (Kenya)A;A 62% A;G 35% G;G 3%
  • Mexican ancestry (Los Angeles)A;A 69% A;G 29% G;G 2%
  • Maasai (Kenya)A;A 70% A;G 28% G;G 2%
  • TuscanA;A 78% A;G 22% G;G 1%

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs911541 increases susceptibility to late-onset Alzheimer's disease 1.58 times for heterozygotes (A;G) and 1.48 times for homozygotes (G;G,) based on a case-control study of ~1,500 Japanese patients and an equal number of matched controls.

Source and license

Adapted from rs911541 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.