rs1800871

rs1800871(C) carriers are associated with a reduced endometriosis risk by approximately 2x compared with the common rs1800871(T;T) genotype in a study of 196 Chinese patients. rs2222202 (C/T) (p=0.03) and rs1800871 (C/T) (p=0.05) showed significant allelic associations with pediatric onset Crohn's disease. rs1800871(T) carriers were 3x more likely to have their pregnancies terminate early (<10 weeks) than (C) carriers, based on a study of ~500 pregnancies. In a study of 1,757 cases of Alzheimer's disease and 6,295 controls, an interaction was replicated between IL6 genotype rs2069837(A;A) and IL10 genotype rs1800871(C;C). The synergy factor (SF) was 1.63 (CI: 1.10-2.41, p = 0.01), controlling for age, gender and ApoE4 genotype. 23andMe reports that each G allele at rs1800871 is associated with 0.6x lower odds of Beh&#231;et's disease. Gene-environment interaction effects on the development of immune responses in the 1st year of life. Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma. Polymorphisms in the genes encoding chemokine receptor 5, interleukin-10, and monocyte chemoattractant protein 1 contribute to cytomegalovirus reactivation and disease after allogeneic stem cell transplantation. Cytokine gene polymorphisms and atopic disease in two European cohorts. (ECRHS-Basel and SAPALDIA). Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery. The interleukin-10 gene promoter polymorphism -1087AG does not correlate with clinical outcome in non-Hodgkin's lymphoma. Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival. Association of IL10 promoter polymorphism in Italian Alzheimer's disease. Genetic polymorphisms and the risk of infection following esophagectomy. positive association with TNF-alpha gene -308 genotype. Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples. Comparison of single nucleotide polymorphisms in the human interleukin-10 gene promoter between rheumatoid arthritis patients and normal subjects in Malaysia. Genetic variation in interleukin-10 gene and risk of oral cancer. Association of TGF-beta1 codon 25 (G915C) polymorphism with hepatitis C virus infection. Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome. Vaccine immunogenetics: bedside to bench to population. Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era. Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China. Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population. Interleukin and interleukin receptor gene polymorphisms and susceptibility to melanoma. Prevalence in the United States of selected candidate gene variants: Third National Health and Nutrition Examination Survey, 1991-1994. Large-scale evaluation of candidate genes identifies associations between DNA repair and genomic maintenance and development of benzene hematotoxicity. Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma. Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies. Association of IL-10 and IL-10Rbeta gene polymorphisms with graft-versus-host disease after haematopoietic stem cell transplantation from an HLA-identical sibling donor. IL10 haplotype associated with tuberculin skin test response but not with pulmonary TB. Toll-like receptor signaling pathway variants and prostate cancer mortality. Genetic polymorphisms, their allele combinations and IFN-beta treatment response in Irish multiple sclerosis patients. IL-10 and TNF-alpha promoter haplotypes are associated with childhood Crohn's disease location. Genetic factors associated with intestinal metaplasia in a high risk Singapore-Chinese population: a cohort study. Asthma and genes encoding components of the vitamin D pathway. Selection for genetic variation inducing pro-inflammatory responses under adverse environmental conditions in a Ghanaian population. Radiographic severity of knee osteoarthritis is conditional on interleukin 1 receptor antagonist gene variations. Influence of cytokine gene polymorphisms on prostate-specific antigen recurrence in prostate cancer after radical prostatectomy. Single nucleotide polymorphisms of 8 inflammation-related genes and their associations with smoking-related cancers. Cytokine signaling pathway polymorphisms and AIDS-related non-Hodgkin lymphoma risk in the multicenter AIDS cohort study. Analysis of eight genes modulating interferon gamma and human genetic susceptibility to tuberculosis: a case-control association study. Lack of association between the IL-10 gene polymorphisms and features of the metabolic syndrome. The effect of IL-10 genetic variation and interleukin 10 serum levels on Crohn's disease susceptibility in a New Zealand population. Polymorphisms in genes controlling inflammation and tissue repair in rheumatoid arthritis: a case control study. Polymorphisms of interleukin-10 promoter are not associated with prognosis of advanced gastric cancer. Joint effects of Epstein-Barr virus and polymorphisms in interleukin-10 and interferon-gamma on breast cancer risk. Interleukin-10 promoter microsatellite polymorphisms influence the immune response to heparin and the risk of heparin-induced thrombocytopenia. Association of the interleukin-10 1082G/A, 819C/T and 3575T/A gene polymorphisms with systemic sclerosis: a meta-analysis. The IL-10 promoter haplotype and cancer risk: evidence from a meta-analysis.

A;A

Although rare for caucasians, normal for the asian population studied. The common TT genotype. increases a risk for endometriosis. Both the CT and the CC genotypes had a reduced risk for endometriosis by approximately 50% compared with the TT genotype.