rs1800896

A SNP in the IL10 gene on chromosome 1. Its most notable genotype is T;T: 1.8x increased prostate cancer risk

Gene
IL10
Location
Chr 1206,773,552 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
30%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad1.8x increased prostate cancer riskWorth knowing · 2.054% of people
  2. C;TBad1.6x increased prostate cancer riskWorth knowing · 2.035% of people
  3. C;CGoodNormal prostate cancer riskMinor · 1.011% of people

SNPedia records rs1800896 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 54% C;T 35% C;C 11%
  • European ancestry (Utah)T;T 21% C;T 51% C;C 27%
  • Han Chinese (Beijing)T;T 90% C;T 10% C;C 0%
  • Japanese (Tokyo)T;T 91% C;T 8% C;C <1%
  • Yoruba (Nigeria)T;T 54% C;T 37% C;C 9%
  • African ancestry (Southwest US)T;T 44% C;T 42% C;C 14%
  • Chinese (Denver)T;T 88% C;T 12% C;C 0%
  • Gujarati IndianT;T 54% C;T 38% C;C 8%
  • Luhya (Kenya)T;T 39% C;T 50% C;C 11%
  • Mexican ancestry (Los Angeles)T;T 47% C;T 45% C;C 9%
  • Maasai (Kenya)T;T 31% C;T 56% C;C 13%
  • TuscanT;T 37% C;T 36% C;C 27%

Conditions, medicines and genes

Other IL10 SNPs

All IL10 SNPs

Notes

From SNPedia

Show notes, about 120 words

This SNP is upstream of the IL10 gene, and is also known as the -1082G>A IL10 SNP. Dust mite exposure modifies the effect of functional IL10 polymorphisms on allergy and asthma exacerbations. Dust mite exposure significantly modified the relation between 3 SNPs in IL10 (rs1800896, rs3024492, and rs3024496). Homozygosity for the minor allele of each of the 3 SNPs was associated with increased risk of occurrence ( approximately 3-fold to 39-fold increase). A study of 258 prostate cancer cases concluded that the rs1800896(A) allele, known to result in lower levels of this anti-inflammatory cytokine, was positively associated with risk (AG vs. GG, odds ratio of 1.69, CI: 1.10-2.60; AA vs. GG, OR of 1.81, CI: 1.11-2.96).

Source and license

Adapted from rs1800896 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.