rs2297404
A SNP in the ABCA1 gene on chromosome 9. Its most notable genotype is G;G.
- Gene
- ABCA1
- Location
- Chr 9104,802,185 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe
- Minor allele frequency
- 9%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs2297404 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 2%
- European ancestry (Utah)G;G 2%
- Han Chinese (Beijing)G;G 4%
- Japanese (Tokyo)G;G 2%
- Yoruba (Nigeria)G;G 0%
Related
Conditions, medicines and genes
Other ABCA1 SNPs
- rs4149268C;Tassociated with higher HDL cholesterolWorth knowing
- rs4149274G;GAssociated with higher HDL (good) cholesterol.Minor
- rs363717C;Ccommon in clinvarTypical
- rs2066714T;Tcommon in clinvarTypical
- rs2066715C;Ccommon in complete genomicsTypical
- rs2230808T;Tcommon in clinvarTypical
- rs2515629A;Acommon in complete genomicsTypical
- rs2853579G;Gcommon in clinvarTypical
Notes
From SNPedia
Notes
rs2297404, rs2230808, and rs2020927 haplotype (CAC) was more prevalent in the Alzheimer's disease group (0.323 in AD vs. 0.202 in control); while haplotype1 (TGG) was over-represented in the healthy controls (0.595 in control vs. 0.493 in AD)
G;G
appears to be common on the 23andMe platform
Source and license
Adapted from rs2297404 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.