rs4149268
A SNP in the ABCA1 gene on chromosome 9. Its most notable genotype is C;T: associated with higher HDL cholesterol
- Gene
- ABCA1
- Location
- Chr 9104,884,939 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 42%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- C;TMost notableGoodassociated with higher HDL cholesterol
- C;CGoodassociated with higher HDL cholesterol
SNPedia records rs4149268 on the minus strand: (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;T 42% C;C 29%
- European ancestry (Utah)C;T 40% C;C 52%
- Han Chinese (Beijing)C;T 42% C;C 53%
- Japanese (Tokyo)C;T 43% C;C 42%
- Yoruba (Nigeria)C;T 43% C;C 6%
- African ancestry (Southwest US)C;T 39% C;C 7%
- Chinese (Denver)C;T 44% C;C 48%
- Gujarati IndianC;T 43% C;C 19%
- Luhya (Kenya)C;T 46% C;C 7%
- Mexican ancestry (Los Angeles)C;T 40% C;C 45%
- Maasai (Kenya)C;T 40% C;C 5%
- TuscanC;T 41% C;C 38%
Related
Conditions, medicines and genes
Other ABCA1 SNPs
- rs4149274G;GAssociated with higher HDL (good) cholesterol.Minor
- rs363717C;Ccommon in clinvarTypical
- rs2066714T;Tcommon in clinvarTypical
- rs2066715C;Ccommon in complete genomicsTypical
- rs2230808T;Tcommon in clinvarTypical
- rs2297404G;GNo summary available.Typical
- rs2515629A;Acommon in complete genomicsTypical
- rs2853579G;Gcommon in clinvarTypical
Notes
From SNPedia
Notes
G allele is associated with 0.82mg/dl increase in HDL cholesterol (good cholesterol).
Source and license
Adapted from rs4149268 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.