rs4149274
A SNP in the ABCA1 gene on chromosome 9. Its most notable genotype is G;G: Associated with higher HDL (good) cholesterol.
- Gene
- ABCA1
- Location
- Chr 9104,877,133 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 29%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GMost notableGoodAssociated with higher HDL (good) cholesterol.
- A;GGoodassociated with higher HDL (good) cholesterol
SNPedia records rs4149274 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 3 HapMap populations.
- AverageG;G 57% A;G 40%
- European ancestry (Utah)G;G 62% A;G 36%
- Han Chinese (Beijing)G;G 61% A;G 39%
- Japanese (Tokyo)G;G 48% A;G 45%
Related
Conditions, medicines and genes
Other ABCA1 SNPs
- rs4149268C;Tassociated with higher HDL cholesterolWorth knowing
- rs363717C;Ccommon in clinvarTypical
- rs2066714T;Tcommon in clinvarTypical
- rs2066715C;Ccommon in complete genomicsTypical
- rs2230808T;Tcommon in clinvarTypical
- rs2297404G;GNo summary available.Typical
- rs2515629A;Acommon in complete genomicsTypical
- rs2853579G;Gcommon in clinvarTypical
Notes
From SNPedia
Notes
C allele is associated with 1.51mg/dl increase in HDL cholesterol (good cholesterol).
Source and license
Adapted from rs4149274 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.