rs5963409

A SNP in the OTC gene on chromosome X. Its most notable genotype is A;A: 1.19x increased risk for Alzheimer's disease

Gene
OTC
Location
Chr X38,351,716 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe
Minor allele frequency
31%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad1.19x increased risk for Alzheimer's diseaseTypical · 0.0
  2. A;GBad1.19x increased risk for Alzheimer's diseaseTypical · 0.0
  3. G;GGoodnormalTypical · 0.0

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other OTC SNPs

All OTC SNPs

Notes

From SNPedia

Notes

rs5963409 is a SNP in the ornithine carbamoyltransferase OTC gene; this SNP is also known as the -389 G/A SNP. Previous association studies were extended to a population of 2113 Alzheimer's disease cases and 1580 controls from northern France, western France, the United Kingdom and Italy. The rs5963409(A) minor allele was weakly but significantly associated with an increased risk of developing Alzheimer's disease (odds ratio 1.19, p = 0.004). This association was independent of age and ApoE status.

Source and license

Adapted from rs5963409 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.