rs7653

rs7653 represents a rare variant in the SAR1A gene on chromosome 10. A 2017 publication reports that the rs7653(C) allele may be associated with a lower odds of developing Alzheimer's disease in individuals otherwise at higher risk for the disorder. In ~400 individuals from the ADNI cohort tested, the rs7653(C) allele carriers had an odds ratio of 0.35 (p value = 0.0049) compared to non-carriers; however, in ~500 individuals from the CCS cohort subsequently tested, rs7653(C) carriers did not have a statistically significant difference from non-carriers, even though the authors reported that the association was in the "predicted positive direction". This is in contrast to the findings associated with rs142787485, which were significant in both cohorts. The 2017 publication describes the same research cited in a report from ICAD 2016 (page 4 and page 9 of this pdf.