rs3747742

A SNP in the TREML2 gene on chromosome 6. Its most notable genotype is G;G.

Gene
TREML2
Location
Chr 641,194,780 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. G;GMost notableGoodNo summary available.Worth knowing · 2.00% of people

On SNPedia: (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageG;G 0%
  • European ancestry (Utah)G;G 0%
  • Han Chinese (Beijing)G;G 0%
  • Japanese (Tokyo)G;G 0%
  • Yoruba (Nigeria)G;G 0%
  • African ancestry (Southwest US)G;G 0%
  • Chinese (Denver)G;G 0%
  • Gujarati IndianG;G 0%
  • Luhya (Kenya)G;G 0%
  • Mexican ancestry (Los Angeles)G;G 0%
  • Maasai (Kenya)G;G 0%
  • TuscanG;G 0%

Conditions, medicines and genes

Notes

From SNPedia

Show notes, about 130 words

rs3747742 is a SNP in the Triggering receptor expressed on myeloid cells-like 2 TREML2 gene. See the genotype page rs3747742(G;G). The minor allele of rs3747742 has been reported in a large study (IGAP) to be associated with a reduced risk of Alzheimer's Disease. The protective allele is (G). The odds ratio associated with heterozygotes and homozygotes of the G allele versus the A allele is 0.93 (CI 0.89-0.96). Missense variant in TREML2 protects against Alzheimer's disease

G;G

This SNP in the gene TREML2 has been shown to have a protective effect against Alzheimer's disease. . Those with the GG and AG genotypes have an odds ratio of 0.93 versus the AA genotype for Alzheimer's disease. (dbSNP lists the minor allele as C not G. MAF=0.315. The minor allele is the good one.)

References

Source and license

Adapted from rs3747742 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.