rs429358(C;C)

One of 2 snps which is necessary to identify ApoE4. rs429358(C;C) individuals have an increased risk of developing Alzheimer's disease PMID 15956169. APOE4 differences only affect the brain after age 60. The memory changes that occur from 20 to 60 do not seem to be connected to APOE4 at all. today.reuters.com eurekalert.org Patients with Alzheimer's disease who have at least one ApoE4 allele were found to benefit from a therapy that was ineffective in those who lacked medscape.com Inheritance of the rs1799724(T) allele (a variant in another gene, TNF) appears to synergistically increase the risk of Alzheimer's in APOE4 carriers and is associated with altered CSF Abeta42 levels PMID 15895461 PMID 17192785 The researchers found that on testing DNA samples from 1,086 well-characterized Alzheimer's disease cases, a single SNP (rs4420638) lying 14 kb distal to the ApoE locus has a powerful association with late-onset AD (corrected p value was 5.3 x 10 e-34). No other SNP showed as robust an association. The authors estimated that people with two ApoE4 copies, such as a person with the rs429358(C;C) genotype, have a 25-fold increased risk for developing the disease compared to ApoE3/ApoE3 carriers. alzforum.org