rs145999145

A SNP in the PLD3 gene on chromosome 19. Its most notable genotype is A;A: 2x higher risk for Alzheimers disease

Gene
PLD3
Location
Chr 1940,371,688 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2x higher risk for Alzheimers diseaseWorth knowing · 2.0
  2. A;GBad2x higher risk for Alzheimers diseaseWorth knowing · 2.0
  3. G;GGoodcommonMinor · 1.0

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

rs145999145, also known as Val232Met or V232M, is a SNP in the phospholipase D family, member 3 PLD3 gene on chromosome 19. The rs145999145(G) allele encodes the Val; the (A) allele the Met. A relatively rare variant in this SNP has been linked to a doubling of risk for Alzheimer's disease based on seven independent case-control series with a total of more than 11,000 cases and controls of European descent. Other rare variants in the PLD3 gene may also influence disease risk.

Source and license

Adapted from rs145999145 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.