rs4934

A SNP in the SERPINA3 gene on chromosome 14. Its most notable genotype is A;A: 2.5x increased risk of Azheimer's and decreased age at onset

Gene
SERPINA3
Location
Chr 1494,614,466 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
44%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;AMost notableBad2.5x increased risk of Azheimer's and decreased age at onsetTypical · 0.019% of people
  2. A;GNot ratedNo summary available.Typical · 0.045% of people
  3. G;GGoodNo summary available.Typical · 0.036% of people

On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 19% A;G 45% G;G 36%
  • European ancestry (Utah)A;A 21% A;G 52% G;G 27%
  • Han Chinese (Beijing)A;A 38% A;G 52% G;G 10%
  • Japanese (Tokyo)A;A 39% A;G 46% G;G 15%
  • Yoruba (Nigeria)A;A 1% A;G 31% G;G 67%
  • African ancestry (Southwest US)A;A 2% A;G 51% G;G 47%
  • Chinese (Denver)A;A 36% A;G 51% G;G 13%
  • Gujarati IndianA;A 19% A;G 57% G;G 24%
  • Luhya (Kenya)A;A 4% A;G 33% G;G 64%
  • Mexican ancestry (Los Angeles)A;A 12% A;G 29% G;G 59%
  • Maasai (Kenya)A;A 10% A;G 35% G;G 55%
  • TuscanA;A 26% A;G 53% G;G 22%

Conditions, medicines and genes

Other SERPINA3 SNPs

All SERPINA3 SNPs

Notes

From SNPedia

Notes

rs4934 increases susceptibility to Alzheimer's disease 2.56 times for (A;A) homozygotes systolic blood pressure increased with rs4934(A) finds no association between rs4934 and pulmonary emphysema Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data. The genetics of chronic obstructive pulmonary disease. Lung cancer susceptibility model based on age, family history and genetic variants.

Source and license

Adapted from rs4934 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.