rs10484554

A SNP in the LOC107984146 gene on chromosome 6. Its most notable genotype is C;T: 2.8x increased risk for psoriasis

Gene
LOC107984146
Location
Chr 631,306,778 (GRCh38)
Highest magnitude
2.5Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
11%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommonTypical · 0.075% of people
  2. C;TMost notableBad2.8x increased risk for psoriasisWorth knowing · 2.523% of people
  3. T;TBad~4x increased risk for psoriasisWorth knowing · 2.52% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 75% C;T 23% T;T 2%
  • European ancestry (Utah)C;C 76% C;T 22% T;T 3%
  • Han Chinese (Beijing)C;C 79% C;T 20% T;T <1%
  • Japanese (Tokyo)C;C 95% C;T 6% T;T 0%
  • Yoruba (Nigeria)C;C 94% C;T 6% T;T 0%
  • African ancestry (Southwest US)C;C 81% C;T 19% T;T 0%
  • Chinese (Denver)C;C 80% C;T 19% T;T <1%
  • Gujarati IndianC;C 49% C;T 42% T;T 9%
  • Luhya (Kenya)C;C 64% C;T 35% T;T <1%
  • Mexican ancestry (Los Angeles)C;C 78% C;T 22% T;T 0%
  • Maasai (Kenya)C;C 64% C;T 33% T;T 3%
  • TuscanC;C 63% C;T 32% T;T 5%

Conditions, medicines and genes

Other LOC107984146 SNPs

All LOC107984146 SNPs

Notes

From SNPedia

Show notes, about 170 words

rs10484554 was the most highly significant SNP associated with risk for psoriasis in a large US/UK study. rs10484554 was found to be associated with psoriasis based on a study by the eMERGE network in which electronic medical records were searched to find what clinical associations were associated with selected SNPs. Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study. New insights into the pathogenesis and genetics of psoriatic arthritis. Genome-wide association studies and the genetic dissection of complex traits. The search for host genetic factors of HIV/AIDS pathogenesis in the post-genome era: progress to date and new avenues for discovery. Genome-wide association study SNPs in the human genome diversity project populations: does selection affect unlinked SNPs with shared trait associations? A study of CNVs as trait-associated polymorphisms and as expression quantitative trait loci. Host Genes Important to HIV Replication and Evolution.

Source and license

Adapted from rs10484554 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.