rs9264942

A SNP in the LOC107984146 gene on chromosome 6. Its most notable genotype is C;C: 90% reduction in HIV viral load

Gene
LOC107984146
Location
Chr 631,306,603 (GRCh38)
Highest magnitude
2.2Worth knowing
Tested on
23andMe, AncestryDNA, FamilyTreeDNA
Minor allele frequency
35%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableGood90% reduction in HIV viral loadWorth knowing · 2.214% of people
  2. C;TGood60% reduction in HIV viral loadWorth knowing · 2.146% of people
  3. T;TNot ratednormalTypical · 0.040% of people

On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageC;C 14% C;T 46% T;T 40%
  • European ancestry (Utah)C;C 10% C;T 49% T;T 42%
  • Han Chinese (Beijing)C;C 15% C;T 46% T;T 39%
  • Japanese (Tokyo)C;C 17% C;T 47% T;T 36%
  • Yoruba (Nigeria)C;C 5% C;T 37% T;T 58%
  • African ancestry (Southwest US)C;C 12% C;T 47% T;T 40%
  • Chinese (Denver)C;C 16% C;T 49% T;T 36%
  • Gujarati IndianC;C 28% C;T 46% T;T 27%
  • Luhya (Kenya)C;C 10% C;T 43% T;T 47%
  • Mexican ancestry (Los Angeles)C;C 19% C;T 41% T;T 40%
  • Maasai (Kenya)C;C 14% C;T 44% T;T 43%
  • TuscanC;C 10% C;T 60% T;T 30%

Conditions, medicines and genes

Other LOC107984146 SNPs

All LOC107984146 SNPs

Notes

From SNPedia

Show notes, about 250 words

This SNP (C/T) is in 5' region of the HLA-C gene, 35 kb away from transcription initiation in or around the HLA-C gene. "People with this tiny sequence variation, dubbed rs9264942, appear to have up to 90% less virus in their systems than those who carry other polymorphisms. About 10% of Europeans appear to carry two copies of rs9264942, which leads to an average 90% viral load reduction. About 50% of Europeans carry one copy, which gives a 60% reduction. By comparison, less than 40% of people of African descent appear to carry a single copy of the polymorphism." Genetic variation may lower HIV load by 90% They are referring to the (C;C) genotype giving a 90% reduction and the (C;T) giving a 60% reduction. dbSNP page This SNP is also reported to account for 6.5% of the 15% variation in viral load set point in asymptomatic HIV infected individuals. rs2395029 can also be associated with reduced HIV viral load set point.

C;C

The rs9264942(C;C) genotype is reported to be associated with a 90% reduction in viral load in HIV-infected individuals. PMID 17641165 See also rs9264942 and HIV.

C;T

The rs9264942(C;T) genotype is reported to be associated with a 60% reduction in viral load in HIV-infected individuals. PMID 17641165 See also rs9264942 and HIV.

T;T

The rs9264942(T;T) genotype is the common genotype, against which the rs9264942(C;T) and rs9264942(T;T) genotypes associated with reduced viral load in HIV carriers are compared. PMID 17641165 See also rs9264942 and HIV.

References

Source and license

Adapted from rs9264942 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.