rs2395029(G;G)

HLA-B*5701 homozygote likely if Caucasian or Hispanic; high risk for hypersensitivity to various drugs including abacavir; 2x psoriasis risk; see details

Magnitude
4.0Very important
Repute
Bad
Frequency
<1%Average of 11 populations
On SNPedia
rs2395029(G;G)
Gene
HCP5

Frequency

Share of people with G;G in each HapMap population.

  • Maasai (Kenya)1%
  • Gujarati Indian1%
  • European ancestry (Utah)0%
  • Han Chinese (Beijing)0%
  • Japanese (Tokyo)0%
  • Yoruba (Nigeria)0%
  • African ancestry (Southwest US)0%
  • Chinese (Denver)0%
  • Luhya (Kenya)0%
  • Mexican ancestry (Los Angeles)0%
  • Tuscan0%

Other genotypes of rs2395029

  1. G;TBadHLA-B*5701 carrier most likely (if Caucasian or Hispanic)Important · 3.28% of people
  2. T;TGoodcommonTypical · 0.091% of people

All about rs2395029

Notes

From SNPedia

23andMe blog rs2395029(G;G) increases the odds of drug-induced liver injury in response to flucloxacillin by 45x marker HLA-B*5701 hypersensitivity to the HIV drug abacavir an HIV viral load 2 logs lower than the most common genotype PMID 17641165

References

Source and license

Adapted from rs2395029(G;G) on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.