rs6887695

A SNP on chromosome 5. Its most notable genotype is C;C: normal

Gene
None listed
Location
Chr 5159,395,637 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
40%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableNot ratednormalTypical · 0.018% of people
  2. C;GNot ratedNo summary available.Typical · 0.046% of people
  3. G;GBad1.4x increased risk of psoriasis, psoriatic arthritisTypical · 0.036% of people

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 10 HapMap populations.

  • AverageC;C 18% C;G 46% G;G 36%
  • European ancestry (Utah)C;C 9% C;G 47% G;G 44%
  • Han Chinese (Beijing)C;C 14% C;G 50% G;G 36%
  • Japanese (Tokyo)C;C 23% C;G 40% G;G 37%
  • Yoruba (Nigeria)C;C 24% C;G 51% G;G 25%
  • African ancestry (Southwest US)C;C 20% C;G 39% G;G 41%
  • Chinese (Denver)C;C 19% C;G 52% G;G 29%
  • Gujarati IndianC;C 16% C;G 47% G;G 37%
  • Mexican ancestry (Los Angeles)C;C 19% C;G 35% G;G 47%
  • Maasai (Kenya)C;C 24% C;G 51% G;G 25%
  • TuscanC;C 14% C;G 50% G;G 36%

Conditions, medicines and genes

Notes

From SNPedia

Notes

IL12B gene SNP, part of a haplotype with rs3212227 associated with psoriasis. rs6887695 confirmed to be associated with psoriasis in another study A study of 500+ patients with psoriatic arthritis (PsA) concluded that the odds ratio for rs6887695(G;G) carriers was 1.43 (CI: 1.18-1.74). The effect sizes observed in patients with PsA appear to be smaller than those previously reported in patients with psoriasis, suggesting that both loci are primarily associated with psoriasis susceptibility rather than primarily with psoriatic arthritis.

Source and license

Adapted from rs6887695 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.