rs7530511
A SNP in the IL23R gene on chromosome 1. Its most notable genotype is T;T: 9x increased risk for Graves disease
- Gene
- IL23R
- Location
- Chr 167,219,704 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 13%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageC;C 79% C;T 18% T;T 3%
- European ancestry (Utah)C;C 77% C;T 20% T;T 3%
- Han Chinese (Beijing)C;C 99% C;T <1% T;T 0%
- Japanese (Tokyo)C;C 96% C;T 4% T;T 0%
- Yoruba (Nigeria)C;C 54% C;T 33% T;T 13%
- African ancestry (Southwest US)C;C 53% C;T 44% T;T 4%
- Chinese (Denver)C;C 97% C;T 3% T;T 0%
- Gujarati IndianC;C 88% C;T 12% T;T 0%
- Luhya (Kenya)C;C 67% C;T 28% T;T 5%
- Mexican ancestry (Los Angeles)C;C 83% C;T 16% T;T 2%
- Maasai (Kenya)C;C 85% C;T 14% T;T <1%
- TuscanC;C 74% C;T 25% T;T 2%
Related
Conditions, medicines and genes
Other IL23R SNPs
- rs11209026A;A0.26x lower risk for certain autoimmune diseases.Important
- rs2201841T;TNo summary available.Worth knowing
- rs10889677A;C1.5x increased risk for certain autoimmune diseases; 2x increased risk for Graves diseaseWorth knowing
- rs11465770C;Tpossibly lower risk of Crohn's Disease (OR=0.30)Minor
- rs11465804G;G0.68x lower risk for spondylitisMinor
- rs1004819G;G1.5x risk of Crohn's disease, 1.2 for developing ankylosing spondylitisMinor
- rs1343151G;Gnormal riskTypical
- rs1495965T;T1.2x higher risk for spondylitisTypical
Notes
From SNPedia
Notes
IL23R gene SNP, part of a haplotype with rs11209026 associated with psoriasis. In a study of 216 North American patients with Graves' disease, the homozygous rs10889677(T;T) genotype was significantly associated with Graves' disease but not specifically with Graves ophthalmopathy; the odds ratio was 9.4 (p=0.02).
Source and license
Adapted from rs7530511 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.