rs1495965

A SNP in the IL23R gene on chromosome 1. Its most notable genotype is T;T: 1.2x higher risk for spondylitis

Gene
IL23R
Location
Chr 167,287,825 (GRCh38)
Highest magnitude
0.0Typical
Tested on
23andMe, AncestryDNA
Minor allele frequency
45%

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. T;TMost notableBad1.2x higher risk for spondylitisTypical · 0.031% of people
  2. C;TBad1.2x higher risk for spondylitisTypical · 0.049% of people
  3. C;CNot ratednormal riskTypical · 0.020% of people
  4. A;ANot ratedNo summary available.Typical · 0.00% of people

SNPedia records rs1495965 on the minus strand: (A;A), (A;G), (G;G), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageT;T 31% C;T 49% C;C 20% A;A 0%
  • European ancestry (Utah)T;T 36% C;T 46% C;C 18% A;A 0%
  • Han Chinese (Beijing)T;T 22% C;T 55% C;C 23% A;A 0%
  • Japanese (Tokyo)T;T 32% C;T 50% C;C 19% A;A 0%
  • Yoruba (Nigeria)T;T 28% C;T 53% C;C 19% A;A 0%
  • African ancestry (Southwest US)T;T 28% C;T 51% C;C 21% A;A 0%
  • Chinese (Denver)T;T 24% C;T 50% C;C 26% A;A 0%
  • Gujarati IndianT;T 22% C;T 49% C;C 30% A;A 0%
  • Luhya (Kenya)T;T 37% C;T 44% C;C 19% A;A 0%
  • Mexican ancestry (Los Angeles)T;T 52% C;T 41% C;C 7% A;A 0%
  • Maasai (Kenya)T;T 29% C;T 50% C;C 21% A;A 0%
  • TuscanT;T 28% C;T 51% C;C 21% A;A 0%

Conditions, medicines and genes

Other IL23R SNPs

All IL23R SNPs

Notes

From SNPedia

Show notes, about 260 words

rs1495965 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 1.2 (p=6.6x10e-6).PMID 17952073, PMID 18037607 23andMe reports that the CC genotype at rs1495965 is associated with 1.56x higher odds of Behçet's disease, and the TT genotype with 0.64x lower odds, than the CT genotype. rs11209032 and rs1495965 no significant association with systemic sclerosis A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort. rs1004819 is the main disease-associated IL23R variant in German Crohn's disease patients: combined analysis of IL23R, CARD15, and OCTN1/2 variants. CARD15 and IL23R influences Crohn's disease susceptibility but not disease phenotype in a Brazilian population. IL23R haplotypes provide a large population attributable risk for Crohn's disease. IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease. No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus. Evidence for STAT4 as a common autoimmune gene: rs7574865 is associated with colonic Crohn's disease and early disease onset. An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians. Association study of IL10 and IL23R-IL12RB2 in Iranian patients with Behcet's disease.

Source and license

Adapted from rs1495965 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.