rs10889677

A SNP in the IL23R gene on chromosome 1. Its most notable genotype is A;C: 1.5x increased risk for certain autoimmune diseases; 2x increased risk for Graves disease

Gene
IL23R
Location
Chr 167,259,437 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe, AncestryDNA
Minor allele frequency
36%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. A;ABad1.5x increased risk for certain autoimmune diseasesMinor · 1.521% of people
  2. A;CMost notableBad1.5x increased risk for certain autoimmune diseases; 2x increased risk for Graves diseaseWorth knowing · 2.038% of people
  3. C;CBadBaseline (average) risk for certain autoimmune diseases; however, 2.3x increased risk for Graves diseaseWorth knowing · 2.041% of people

On SNPedia: (A;A), (A;C), (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Frequency

Share of each genotype in 11 HapMap populations.

  • AverageA;A 21% A;C 38% C;C 41%
  • European ancestry (Utah)A;A 10% A;C 39% C;C 51%
  • Han Chinese (Beijing)A;A 51% A;C 41% C;C 8%
  • Japanese (Tokyo)A;A 49% A;C 38% C;C 13%
  • Yoruba (Nigeria)A;A 1% A;C 22% C;C 77%
  • African ancestry (Southwest US)A;A 0% A;C 30% C;C 70%
  • Chinese (Denver)A;A 51% A;C 44% C;C 5%
  • Gujarati IndianA;A 38% A;C 46% C;C 17%
  • Luhya (Kenya)A;A 6% A;C 29% C;C 65%
  • Mexican ancestry (Los Angeles)A;A 10% A;C 35% C;C 55%
  • Maasai (Kenya)A;A 9% A;C 44% C;C 47%
  • TuscanA;A 6% A;C 52% C;C 43%

Conditions, medicines and genes

Other IL23R SNPs

All IL23R SNPs

Notes

From SNPedia

Show notes, about 150 words

SNP rs10889677, in the IL23R gene, is associated with increased risk for Crohn's disease in both Jewish and non-Jewish populations. The same risk allele for this SNP has been associated with increased risk for ankylosing spondylitis in a large study of over 1,000 Caucasian patients. The odds ratio is 1.3 (p=1.3x10e-6).PMID 17952073, PMID 18037607 In a study of 216 North American patients with Graves' disease, the C allele of rs10889677 was 2.03x overrepresented (p=1.3x10 –4 ), and the homozygous rs10889677(C;C) genotype was also overrepresented (2.36x; p=1.4x10 -4 ) in Graves ophthalmopathy patients. A genome-wide association study using DNA samples from 1,052 individuals with ulcerative colitis and preexisting data from 2,571 controls, all of European ancestry, concluded that this SNP and several others were associated with altered risk for the disease.

Source and license

Adapted from rs10889677 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.