rs1343151
A SNP in the IL23R gene on chromosome 1. Its most notable genotype is G;G: normal risk
- Gene
- IL23R
- Location
- Chr 167,253,446 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 32%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- G;GMost notableNot ratednormal risk
- A;GGood0.8x lower risk for spondylitis
- A;AGood0.8x lower risk for spondylitis
SNPedia records rs1343151 on the minus strand: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageG;G 49% A;G 34% A;A 17%
- European ancestry (Utah)G;G 49% A;G 37% A;A 14%
- Han Chinese (Beijing)G;G 92% A;G 8% A;A 0%
- Japanese (Tokyo)G;G 82% A;G 17% A;A <1%
- Yoruba (Nigeria)G;G 10% A;G 35% A;A 55%
- African ancestry (Southwest US)G;G 9% A;G 65% A;A 26%
- Chinese (Denver)G;G 95% A;G 5% A;A 0%
- Gujarati IndianG;G 71% A;G 28% A;A 1%
- Luhya (Kenya)G;G 11% A;G 40% A;A 49%
- Mexican ancestry (Los Angeles)G;G 59% A;G 35% A;A 7%
- Maasai (Kenya)G;G 17% A;G 58% A;A 25%
- TuscanG;G 45% A;G 44% A;A 12%
Related
Conditions, medicines and genes
Other IL23R SNPs
- rs11209026A;A0.26x lower risk for certain autoimmune diseases.Important
- rs2201841T;TNo summary available.Worth knowing
- rs7530511T;T9x increased risk for Graves diseaseWorth knowing
- rs10889677A;C1.5x increased risk for certain autoimmune diseases; 2x increased risk for Graves diseaseWorth knowing
- rs11465770C;Tpossibly lower risk of Crohn's Disease (OR=0.30)Minor
- rs11465804G;G0.68x lower risk for spondylitisMinor
- rs1004819G;G1.5x risk of Crohn's disease, 1.2 for developing ankylosing spondylitisMinor
- rs1495965T;T1.2x higher risk for spondylitisTypical
Notes
From SNPedia
Notes
rs1343151 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 0.8 (p=1.0x10e-5).PMID 17952073, PMID 18037607 rs1343151 with rheumatoid arthritis (OR=1.14 [1.06-1.22], P=4x10-4) rs1343151 was not associated with rheumatoid arthritis in a study of 1,200+ Korean patients. A;A homozygous individuals showed a strongly reduced risk of Crohn's Disease compared those who were G;G homozygous.
Source and license
Adapted from rs1343151 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.