rs11465804
A SNP in the IL23R gene on chromosome 1. Its most notable genotype is G;G: 0.68x lower risk for spondylitis
- Gene
- IL23R
- Location
- Chr 167,236,843 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 4%
Genotypes
As shown in 23andMe and AncestryDNA files.
- G;GMost notableGood0.68x lower risk for spondylitis
- G;TGood0.68x lower risk for spondylitis
- T;TBadnormal risk
On SNPedia: (G;G), (G;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 9 HapMap populations.
- AverageG;G <1% G;T 8% T;T 91%
- European ancestry (Utah)G;G 0% G;T 9% T;T 91%
- Han Chinese (Beijing)G;G 0% G;T 0% T;T 100%
- Japanese (Tokyo)G;G 0% G;T 0% T;T 100%
- Yoruba (Nigeria)G;G <1% G;T 5% T;T 95%
- African ancestry (Southwest US)G;G 0% G;T 9% T;T 91%
- Luhya (Kenya)G;G 0% G;T 6% T;T 95%
- Mexican ancestry (Los Angeles)G;G 2% G;T 16% T;T 83%
- Maasai (Kenya)G;G 1% G;T 14% T;T 85%
- TuscanG;G 1% G;T 16% T;T 83%
Related
Conditions, medicines and genes
Other IL23R SNPs
- rs11209026A;A0.26x lower risk for certain autoimmune diseases.Important
- rs2201841T;TNo summary available.Worth knowing
- rs7530511T;T9x increased risk for Graves diseaseWorth knowing
- rs10889677A;C1.5x increased risk for certain autoimmune diseases; 2x increased risk for Graves diseaseWorth knowing
- rs11465770C;Tpossibly lower risk of Crohn's Disease (OR=0.30)Minor
- rs1004819G;G1.5x risk of Crohn's disease, 1.2 for developing ankylosing spondylitisMinor
- rs1343151G;Gnormal riskTypical
- rs1495965T;T1.2x higher risk for spondylitisTypical
Notes
From SNPedia
Notes
rs11465804 is one of several SNPs in the IL23R gene that has been shown in a large (over 1,000 Caucasian patients) study to be associated with ankylosing spondylitis. The odds ratio is 0.68 (p=0.0002).PMID 17952073, PMID 18037607
Source and license
Adapted from rs11465804 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.