rs2201841
A SNP in the IL23R gene on chromosome 1. Its most notable genotype is T;T.
- Gene
- IL23R
- Location
- Chr 167,228,519 (GRCh38)
- Highest magnitude
- 2.0Worth knowing
- Tested on
- 23andMe, AncestryDNA
- Minor allele frequency
- 37%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableNot ratedNo summary available.
- G;GBad1.5x increased risk for Crohn's disease
- A;GBad1.5x increased risk for Crohn's disease; 2x increased risk for Graves' disease
- A;ABad2.4x increased risk for Graves' disease
SNPedia records rs2201841 on the minus strand: (A;A), (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageT;T 0% G;G 21% A;G 39% A;A 41%
- European ancestry (Utah)T;T 0% G;G 11% A;G 38% A;A 51%
- Han Chinese (Beijing)T;T 0% G;G 51% A;G 41% A;A 8%
- Japanese (Tokyo)T;T 0% G;G 48% A;G 39% A;A 14%
- Yoruba (Nigeria)T;T 0% G;G 2% A;G 25% A;A 74%
- African ancestry (Southwest US)T;T 0% G;G 0% A;G 30% A;A 70%
- Chinese (Denver)T;T 0% G;G 51% A;G 44% A;A 5%
- Gujarati IndianT;T 0% G;G 37% A;G 46% A;A 17%
- Luhya (Kenya)T;T 0% G;G 6% A;G 29% A;A 66%
- Mexican ancestry (Los Angeles)T;T 0% G;G 9% A;G 36% A;A 55%
- Maasai (Kenya)T;T 0% G;G 10% A;G 44% A;A 46%
- TuscanT;T 0% G;G 6% A;G 52% A;A 42%
Related
Conditions, medicines and genes
Other IL23R SNPs
- rs11209026A;A0.26x lower risk for certain autoimmune diseases.Important
- rs7530511T;T9x increased risk for Graves diseaseWorth knowing
- rs10889677A;C1.5x increased risk for certain autoimmune diseases; 2x increased risk for Graves diseaseWorth knowing
- rs11465770C;Tpossibly lower risk of Crohn's Disease (OR=0.30)Minor
- rs11465804G;G0.68x lower risk for spondylitisMinor
- rs1004819G;G1.5x risk of Crohn's disease, 1.2 for developing ankylosing spondylitisMinor
- rs1343151G;Gnormal riskTypical
- rs1495965T;T1.2x higher risk for spondylitisTypical
Notes
From SNPedia
Notes
SNP rs2201841, in the IL23R gene, is associated with increased risk for Crohn's disease in both Jewish and non-Jewish populations. Another study found that the "A allele" and "AA genotype" were significantly overrepresented in Graves' disease patients with Graves ophthalmopathy, based on 216 North American patients. The odds ratios reported were 2.04 for the allele (p=1x10 -4 ), and for the so-called "AA" genotype (presumably rs2201841(T;T) when correctly oriented to the dbSNP orientation), 2.4 (p=1x10 -4 ). 23andMe blog psoriasis Europeans *rs2201841(G) 1.13x risk
Source and license
Adapted from rs2201841 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.