rs11465770
A SNP in the IL23R gene on chromosome 1. Its most notable genotype is C;T: possibly lower risk of Crohn's Disease (OR=0.30)
- Gene
- IL23R
- Location
- Chr 167,168,280 (GRCh38)
- Highest magnitude
- 1.5Minor
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 4%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CNot ratednormal Crohn's Disease risk
- C;TMost notableNot ratedpossibly lower risk of Crohn's Disease (OR=0.30)
- T;TNot ratedpossibly lower risk of Crohn's Disease (OR=0.30)
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 10 HapMap populations.
- AverageC;C 93% C;T 7% T;T <1%
- European ancestry (Utah)C;C 84% C;T 15% T;T <1%
- Han Chinese (Beijing)C;C 99% C;T <1% T;T 0%
- Japanese (Tokyo)C;C 100% C;T 0% T;T 0%
- Yoruba (Nigeria)C;C 99% C;T <1% T;T 0%
- African ancestry (Southwest US)C;C 95% C;T 5% T;T 0%
- Gujarati IndianC;C 82% C;T 18% T;T 0%
- Luhya (Kenya)C;C 99% C;T <1% T;T 0%
- Mexican ancestry (Los Angeles)C;C 95% C;T 5% T;T 0%
- Maasai (Kenya)C;C 96% C;T 5% T;T 0%
- TuscanC;C 79% C;T 20% T;T 1%
Related
Conditions, medicines and genes
Other IL23R SNPs
- rs11209026A;A0.26x lower risk for certain autoimmune diseases.Important
- rs2201841T;TNo summary available.Worth knowing
- rs7530511T;T9x increased risk for Graves diseaseWorth knowing
- rs10889677A;C1.5x increased risk for certain autoimmune diseases; 2x increased risk for Graves diseaseWorth knowing
- rs11465804G;G0.68x lower risk for spondylitisMinor
- rs1004819G;G1.5x risk of Crohn's disease, 1.2 for developing ankylosing spondylitisMinor
- rs1343151G;Gnormal riskTypical
- rs1495965T;T1.2x higher risk for spondylitisTypical
Notes
From SNPedia
Notes
Contribution of rs11465788 in IL23R gene to Crohn's disease susceptibility and phenotype in Chinese population. Found that T allele may be protective against Crohn's disease in Chinese.
Source and license
Adapted from rs11465770 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.