rs1800629

This SNP in the tumor necrosis factor-alpha gene, rs1800629, is also known as the TNF-308 SNP. Occasionally the rs1800629(A) allele is referred to as 308.2 or TNF2, with the more common (G) allele being 308.1 or TNF1. The (A) allele is associated with higher levels of TNF expression. This SNP has been linked to a wide variety of conditions: * Allograft rejection ** Among 72 Polish patients receiving a kidney transplant, the risk of acute kidney allograft rejection was 2.5x higher among rs1800629(A) carriers compared to (G;G) homozygotes (CI: 1.19- 5.37, p -6 ). The authors of this research suggest that preemptive anti-inflammatory interventions should be developed for use in carriers of this SNP should they suffer severe injuries. ** A meta-analysis of 25 studies concluded that while rs1800629 status is significantly associated with risk for sepsis, especially among Asians, it was not associated with mortality from sepsis. However, there may be an increased risk for fatal outcomes among Asians (odds ratio 10.75, CI: 3-39, p < 0.01). * Systemic lupus erythematosus (SLE) ** A study of 120 Columbian patients with SLE found an increased risk for rs1800629(A) carriers (odds ratio 3.9, CI: 1.65-5.80, p= 0.0004). ** A meta-analysis of 21 studies indicated that in European populations, the rs1800629(A) allele is associated with increased risk for systemic lupus erythematosus (SLE). In Europeans, the oodds ratio for the (A;A) genotype was 4.0, CI: 2.5-6.4, p<0.001. No association was detected in Asian-derived populations. The overall odds ratio for rs1800629(A) carriers was 2.0 (CI: 1.3-3.1, p<0.001). {{PMID Auto |PMID=20080841 |Title=Additive effect of polymorphisms in the IL-6, LTA, and TNF-{alpha} genes and plasma fatty acid level modulate risk for the metabolic syndrome and its components }}