rs3093662
A SNP in the TNF gene on chromosome 6. Its most notable genotype is A;A: common in complete genomics
- Gene
- TNF
- Location
- Chr 631,576,412 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 7%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 11 HapMap populations.
- AverageA;A 82%
- European ancestry (Utah)A;A 85%
- Han Chinese (Beijing)A;A 93%
- Japanese (Tokyo)A;A 97%
- Yoruba (Nigeria)A;A 88%
- African ancestry (Southwest US)A;A 79%
- Chinese (Denver)A;A 96%
- Gujarati IndianA;A 68%
- Luhya (Kenya)A;A 80%
- Mexican ancestry (Los Angeles)A;A 76%
- Maasai (Kenya)A;A 64%
- TuscanA;A 80%
Related
Other TNF SNPs
- rs3093726C;CProbably an HLA-B*5701 homozygote; high risk for hypersensitivity to various drugs including abacavirVery important
- rs1800629A;Acomplex; generally higher risk for certain diseasesWorth knowing
- rs361525A;Acomplex; generally higher risk for certain diseasesTypical
- rs1800750A;Ahigher acute otitis riskTypical
- rs3093664A;Acommon in complete genomicsTypical
- rs3093665A;Acommon in complete genomicsTypical
- rs3093668G;Gcommon in complete genomicsTypical
- rs4645843C;Ccommon genotypeTypical
Notes
From SNPedia
Show notes, about 190 words
The TNFalpha gene relates to clinical phenotype in alpha-1-antitrypsin deficiency. Association of donor inflammation- and apoptosis-related genotypes and delayed allograft function after kidney transplantation. Functional genetic polymorphisms and female reproductive disorders: part II--endometriosis. Distinct genetic loci control plasma HIV-RNA and cellular HIV-DNA levels in HIV-1 infection: the ANRS Genome Wide Association 01 study. Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia. Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations. Association of MICA with rheumatoid arthritis independent of known HLA-DRB1 risk alleles in a family-based and a case control study. Toll-like receptor signaling pathway variants and prostate cancer mortality. Identification of genes and haplotypes that predict rheumatoid arthritis using random forests. Leprosy and the adaptation of human toll-like receptor 1. Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
Source and license
Adapted from rs3093662 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.