rs4645843
A SNP in the TNF gene on chromosome 6. Its most notable genotype is C;C: common genotype
- Gene
- TNF
- Location
- Chr 631,576,785 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 9 HapMap populations.
- AverageC;C 99%
- European ancestry (Utah)C;C 99%
- Han Chinese (Beijing)C;C 100%
- Japanese (Tokyo)C;C 100%
- Yoruba (Nigeria)C;C 100%
- Chinese (Denver)C;C 99%
- Luhya (Kenya)C;C 99%
- Mexican ancestry (Los Angeles)C;C 98%
- Maasai (Kenya)C;C 99%
- TuscanC;C 98%
Related
Other TNF SNPs
- rs3093726C;CProbably an HLA-B*5701 homozygote; high risk for hypersensitivity to various drugs including abacavirVery important
- rs1800629A;Acomplex; generally higher risk for certain diseasesWorth knowing
- rs361525A;Acomplex; generally higher risk for certain diseasesTypical
- rs1800750A;Ahigher acute otitis riskTypical
- rs3093662A;Acommon in complete genomicsTypical
- rs3093664A;Acommon in complete genomicsTypical
- rs3093665A;Acommon in complete genomicsTypical
- rs3093668G;Gcommon in complete genomicsTypical
Source and license
Adapted from rs4645843 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.