rs3093726
A SNP in the TNF gene on chromosome 6. Its most notable genotype is C;C: Probably an HLA-B*5701 homozygote; high risk for hypersensitivity to various drugs including abacavir
- Gene
- TNF
- Location
- Chr 631,579,012 (GRCh38)
- Highest magnitude
- 4.0Very important
- Tested on
- 23andMe
- Minor allele frequency
- 3%
Genotypes
As shown in 23andMe and AncestryDNA files.
- C;CMost notableBadProbably an HLA-B*5701 homozygote; high risk for hypersensitivity to various drugs including abacavir
- C;TBadcarrier. risk of toxicity from some medications
- T;TGoodnormal
On SNPedia: (C;C), (C;T), (T;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageC;C 0% C;T 3% T;T 97%
- European ancestry (Utah)C;C 0% C;T 8% T;T 92%
- Han Chinese (Beijing)C;C 0% C;T 2% T;T 98%
- Japanese (Tokyo)C;C 0% C;T 0% T;T 100%
- Yoruba (Nigeria)C;C 0% C;T 0% T;T 100%
Related
Other TNF SNPs
- rs1800629A;Acomplex; generally higher risk for certain diseasesWorth knowing
- rs361525A;Acomplex; generally higher risk for certain diseasesTypical
- rs1800750A;Ahigher acute otitis riskTypical
- rs3093662A;Acommon in complete genomicsTypical
- rs3093664A;Acommon in complete genomicsTypical
- rs3093665A;Acommon in complete genomicsTypical
- rs3093668G;Gcommon in complete genomicsTypical
- rs4645843C;Ccommon genotypeTypical
Notes
From SNPedia
Notes
C;C
predictive of the presence of an HLA-B*5701 allele. This HLA allele, in turn, has been associated with several conditions. See rs2395029 for more information.
C;T
predictive of the presence of an HLA-B*5701 allele. This HLA allele, in turn, has been associated with several conditions. See rs2395029 for more information.
Source and license
Adapted from rs3093726 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.