rs1800750
A SNP in the TNF gene on chromosome 6. Its most notable genotype is A;A: higher acute otitis risk
- Gene
- TNF
- Location
- Chr 631,575,186 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 1%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageA;A 0% A;G <1% G;G 99%
- European ancestry (Utah)A;A 0% A;G 2% G;G 99%
- Han Chinese (Beijing)A;A 0% A;G 0% G;G 100%
- Japanese (Tokyo)A;A 0% A;G 0% G;G 100%
- Yoruba (Nigeria)A;A 0% A;G 2% G;G 98%
Related
Other TNF SNPs
- rs3093726C;CProbably an HLA-B*5701 homozygote; high risk for hypersensitivity to various drugs including abacavirVery important
- rs1800629A;Acomplex; generally higher risk for certain diseasesWorth knowing
- rs361525A;Acomplex; generally higher risk for certain diseasesTypical
- rs3093662A;Acommon in complete genomicsTypical
- rs3093664A;Acommon in complete genomicsTypical
- rs3093665A;Acommon in complete genomicsTypical
- rs3093668G;Gcommon in complete genomicsTypical
- rs4645843C;Ccommon genotypeTypical
Notes
From SNPedia
Notes
rs1800750, a SNP located at position -376 of the TNF gene, has been linked to increased risk for recurrent acute otitis in a study of 348 children. The (adjusted) odds ratio is 3.06 for (G;G) genotypes (p=0.07).
Source and license
Adapted from rs1800750 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.