rs3093665
A SNP in the TNF gene on chromosome 6. Its most notable genotype is A;A: common in complete genomics
- Gene
- TNF
- Location
- Chr 631,577,614 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 2%
Genotypes
As shown in 23andMe and AncestryDNA files.
On SNPedia: (A;A). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 9 HapMap populations.
- AverageA;A 94%
- European ancestry (Utah)A;A 97%
- Han Chinese (Beijing)A;A 99%
- Japanese (Tokyo)A;A 100%
- Yoruba (Nigeria)A;A 90%
- African ancestry (Southwest US)A;A 88%
- Luhya (Kenya)A;A 94%
- Mexican ancestry (Los Angeles)A;A 93%
- Maasai (Kenya)A;A 96%
- TuscanA;A 92%
Related
Other TNF SNPs
- rs3093726C;CProbably an HLA-B*5701 homozygote; high risk for hypersensitivity to various drugs including abacavirVery important
- rs1800629A;Acomplex; generally higher risk for certain diseasesWorth knowing
- rs361525A;Acomplex; generally higher risk for certain diseasesTypical
- rs1800750A;Ahigher acute otitis riskTypical
- rs3093662A;Acommon in complete genomicsTypical
- rs3093664A;Acommon in complete genomicsTypical
- rs3093668G;Gcommon in complete genomicsTypical
- rs4645843C;Ccommon genotypeTypical
Notes
From SNPedia
Notes
Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Family-based analysis of tumor necrosis factor and lymphotoxin-alpha tag polymorphisms with type 1 diabetes in the population of South Croatia. Toll-like receptor signaling pathway variants and prostate cancer mortality. Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.
Source and license
Adapted from rs3093665 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.