rs35699176

A SNP in the ZNF77 gene on chromosome 19. Its most notable genotype is A;G: Higher risk for fungal spore related issues in lungs; risk worse in asthmatics?

Gene
ZNF77
Location
Chr 192,936,537 (GRCh38)
Highest magnitude
4.0Very important
Tested on
23andMe, FamilyTreeDNA

Genotypes

Plus strand, as in 23andMe and AncestryDNA files.

  1. G;GGoodcommon/normalTypical · 0.0
  2. A;GMost notableBadHigher risk for fungal spore related issues in lungs; risk worse in asthmatics?Very important · 4.0

SNPedia records rs35699176 on the minus strand: (C;C), (C;T). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Notes

From SNPedia

Notes

aka c.429C>T; a stop-gain mutation in the ZNF77 gene Carriers of a single rs35699176(T) allele are reported to be at risk for a 17-fold increase in the amount of Aspergillus fungal spores in their lungs compared to non-carriers. The buildup of fungal spores can lead to allergic bronchopulmonary aspergillosis (ABPA), a fungal disease that reportedly reduces the quality of life of over 5 million individuals living with asthma.

A;G

see discussion and links via main rs-page

Source and license

Adapted from rs35699176 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.