rs689465
A SNP in the PTGS2 gene on chromosome 1. Its most notable genotype is T;T: 1.5x increased risk for mild asthma
- Gene
- PTGS2
- Location
- Chr 1186,681,714 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- 23andMe, AncestryDNA, FamilyTreeDNA
- Minor allele frequency
- 12%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TMost notableNot rated1.5x increased risk for mild asthma
- C;TNot rated1.35x increased risk for asthma
- C;CNot ratednormal
SNPedia records rs689465 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other PTGS2 SNPs
- rs689466C;C1.4x higher risk for inflammatory bowel diseasesMinor
- rs5270G;Gcommon in complete genomicsTypical
- rs5275G;G0.68x decreased risk for bladder cancerTypical
- rs20415G;GNo summary available.Typical
- rs20417G;GNo summary available.Typical
- rs689469C;CNo summary available.Typical
- rs689470G;GNo summary available.Typical
- rs2206593G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Show notes, about 140 words
rs689465 is a SNP in the PTGS2 gene, also known as COX-2, that has been associated with increased risk for mild asthma based on a study of 663 Australian patients. The odds ratio for mild asthma associated with (A;A) genotypes was 1.5 (CI: 1.12-2.02, p=0.02). Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance. Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis. Interaction of cyclooxygenase-2 promoter polymorphisms with Helicobacter pylori infection and risk of gastric cancer. Functional genetic variations of cyclooxygenase-2 and susceptibility to acute myeloid leukemia in a Chinese population. Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features.
Source and license
Adapted from rs689465 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.