rs5270
A SNP in the PTGS2 gene on chromosome 1. Its most notable genotype is G;G: common in complete genomics
- Gene
- PTGS2
- Location
- Chr 1186,680,587 (GRCh38)
- Highest magnitude
- 0.0Typical
- Tested on
- AncestryDNA
- Minor allele frequency
- <1%
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
SNPedia records rs5270 on the minus strand: (C;C). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Frequency
Share of each genotype in 4 HapMap populations.
- AverageG;G 98%
- European ancestry (Utah)G;G 100%
- Han Chinese (Beijing)G;G 100%
- Japanese (Tokyo)G;G 100%
- Yoruba (Nigeria)G;G 91%
Related
Conditions, medicines and genes
Other PTGS2 SNPs
- rs689466C;C1.4x higher risk for inflammatory bowel diseasesMinor
- rs5275G;G0.68x decreased risk for bladder cancerTypical
- rs20415G;GNo summary available.Typical
- rs20417G;GNo summary available.Typical
- rs689465T;T1.5x increased risk for mild asthmaTypical
- rs689469C;CNo summary available.Typical
- rs689470G;GNo summary available.Typical
- rs2206593G;Gcommon in complete genomicsTypical
Notes
From SNPedia
Notes
rs20415 and rs5270 prostate cancer Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance.
Source and license
Adapted from rs5270 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.