rs5275

rs5275, also known as exon1-+837T>C, is a SNP in the PTGS2 gene. A study of 635 Caucasian bladder cancer patients found a reduced risk associated with the minor (C) allele of rs5275, (odds ratio 0.68, CI: 0.54-0.87, p=0.002, remaining significant after multiple comparison adjustment). (T;T) genotype of PTGS2 8473T>C (rs5275) was significantly correlated with a better survival when compared to the combined T/C and C/C genotype (Hazard ratio [HR] = 0.47; P value = 0.046 and HR = 0.16; P = 0.013, respectively) in colorectal cancer Allellic variants in regulatory regions of cyclooxygenase-2: association with advanced colorectal adenoma. Association of frequent consumption of fatty fish with prostate cancer risk is modified by COX-2 polymorphism. Cyclooxygenase-2 polymorphisms in Parkinson's disease. Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk. A polymorphism in the 3' untranslated region of the gene encoding prostaglandin endoperoxide synthase 2 is not associated with an increase in breast cancer risk: a nested case-control study. Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract. Lack of association of the cyclooxygenase-2 and inducible nitric oxide synthase gene polymorphism with risk of cervical cancer in Korean population. Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studies. Pyrosequencing of polymorphisms in the COX-2 gene (PTGS2) with reported clinical relevance. Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression. Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis. Association of polymorphisms in cyclooxygenase (COX)-2 with coronary and carotid calcium in the Diabetes Heart Study. Common polymorphisms of cyclooxygenase-2 and prostaglandin E2 receptor and increased risk for acute coronary syndrome in coronary artery disease. Low-penetrance alleles predisposing to sporadic colorectal cancers: a French case-controlled genetic association study. Cyclooxygenase-2 gene polymorphisms reduce the risk of oral premalignant lesions. Dietary omega-3 fatty acids, cyclooxygenase-2 genetic variation, and aggressive prostate cancer risk. No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk. Toll-like receptor signaling pathway variants and prostate cancer mortality. TNF superfamily gene polymorphism as prognostic factor in early breast cancer. Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study. Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets. Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study. Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer. Functional polymorphisms of cyclooxygenase-2 gene and risk for hepatocellular carcinoma. Gallbladder cancer predisposition: a multigenic approach to DNA-repair, apoptotic and inflammatory pathway genes. Cyclooxygenase-2 polymorphisms and susceptibility to esophageal cancer: a meta-analysis. The risk of coronary thrombosis with cyclo-oxygenase-2 inhibitors does not vary with polymorphisms in two regions of the cyclo-oxygenase-2 gene. Polymorphisms in COX-2 gene influence prostate cancer susceptibility in a northern Indian cohort. Polymorphisms in cycloxygenase-2 gene and breast cancer prognosis: association between PTGS2 haplotypes and histopathological features. A genetic variant in 3'-untranslated region of cyclooxygenases-2 gene is associated with risk of gastric cancer in a chinese population. Influence of COX-2 and OXTR polymorphisms on treatment outcome in treatment resistant depression.