Colorectal cancer

81 SNPs linked to Colorectal cancer across 32 genes, 45 with a genotype of magnitude 2 or higher.

Type: Condition
SNPs: 81
Notable: 45Magnitude 2 or higher
Well documented: 39
Genes: 32

Linked SNPs

Every genotype, as shown in 23andMe and AncestryDNA files.

rs1052471POLD1Very important
- C;THigh risk of colorectal cancer; endometrial cancer risk also elevatedBad
- T;Tcommon/normalGood
rs483352909POLEVery important
- G;Gcommon/normalGood
- C;GMuch higher risk for colorectal cancerBad
rs1801155APCVery important
- A;Arisk of colon cancer and familial adenomatous polyposis (FAP) which usually progresses to malignancyBad
- A;Trisk of colon cancer; familial adenomatous polyposisBad
- T;Tcommon in complete genomicsGood
rs34612342MUTYHVery important
- T;Tcommon in clinvarGood
- C;Tincreased risk for several cancersBad
- C;Cincreased risk for several cancersBad
rs36053993MUTYHVery important
- T;Tlikely to be at somewhat increased risk for colorectal cancersBad
- C;Tcarrier of a risk allele associated with colorectal polyps and possibly cancersBad
- C;Ccommon in clinvarGood
rs1800497ANKK1Very important
- G;GNormal (A2/A2)Good
- A;GA1/A2: Bad at avoidance of errors. 0.5x lower OCD risk, 0.87x lower Tardive Diskinesia risk, higher ADHD risk. More Alcohol Dependence. Lower risk of Postoperative Nausea. Increased obesity. Bupropion is not effective for smoking cessation.Bad
- A;AA1/A1: Bad at avoidance of errors. 0.25x lower OCD; 0.56x lower Tardive Diskinesia; higher ADHD; 1.4x Alcohol Dependence; lower Postoperative Nausea; Increased obesity; less pleasure response; Bupropion ineffective for smoking cessation.; 2.4x risk for adenoma recurrence.Bad
rs7903146TCF7L2Important
- C;CNormal (lower) risk of Type 2 Diabetes and Gestational Diabetes.Good
- C;T1.4x increased risk for diabetes (and perhaps colon cancer).Bad
- T;T2x increased risk for Type-2 diabetesBad
rs6983267CASC8Important
- G;G1.6x increased risk for prostate cancer; also other cancersBad
- G;T1.3x risk of prostate cancer; aspirin reduces risk of colorectal cancerBad
- T;Tnormal risk for cancers; aspirin reduces risk for colorectal cancerGood
rs4143094GATA3Important
- G;Gno increased risk of colorectal cancer correlated with consumption of processed meatsGood
- G;Tslightly (17%) higher risk of colorectal cancer correlated with consumption of processed meatsBad
- T;Thigher (by 39%) risk for colorectal cancer correlated with consumption of processed meatsBad
rs1042522TP53Important
- G;GLive 3 years longer. Chemotherapy is more effective.Good
- C;GSlightly increased lifespan?Good
- C;CCommon variant. Slightly shorter lifespan.Bad
rs1801166APCImportant
- C;Cincreased colon cancer risk? significance is unclearBad
- C;GSignificance unclear wrt colorectal cancerNot rated
- G;Gcommon in clinvarGood
rs2273535AURKAWorth knowing
- A;AcommonNot rated
- A;Tslightly higher (~1.5x or less) risk for certain cancersBad
- T;Tslightly higher (~1.5x or less) risk for certain cancersBad
rs10411210RHPN2Worth knowing
- C;CNo summary available.Not rated
- T;T1.15x increased risk of colorectal cancerBad
rs266729ADIPOQWorth knowing
- C;CnormalNot rated
- C;G0.73x decreased risk for colorectal cancerGood
- G;G0.73x decreased risk for colorectal cancerGood
rs1799732DRD2Worth knowing
- -;-less favorable clinical outcome when on antipsychoticsBad
- -;G1.3x increased adenoma recurrence riskBad
- G;GnormalGood
rs2965667Worth knowing
- A;Aaspirin use may increase colorectal cancer risk a bitBad
- A;Taspirin use may increase colorectal cancer risk a bitBad
- T;Tcommon/normal; aspirin use reduces colorectal cancer risk a bitGood
rs3802842COLCA2Worth knowing
- A;AnormalNot rated
- A;C1.17x increased risk of colorectal cancerBad
- C;C>1.17x increased risk of colorectal cancerBad
rs4464148SMAD7Worth knowing
- C;C1.35x increased risk for colorectal cancerBad
- C;T1.10x increased risk for colorectal cancerBad
- T;TNormal risk for colorectal cancerGood
rs4779584Worth knowing
- C;CaverageGood
- C;T1.23x risk for colorectal cancerBad
- T;T1.70x risk for colorectal cancerBad
rs10505806Worth knowing
- A;Acommon/normal; aspirin use reduces colorectal cancer risk a bitGood
- A;Taspirin use may increase colorectal cancer risk a bitBad
- T;Taspirin use may increase colorectal cancer risk a bitBad
rs16888589Worth knowing
- A;AnormalGood
- A;G1.4x higher risk for colorectal cancerNot rated
- G;G1.9x higher risk for colorectal cancerNot rated
rs16892766Worth knowing
- A;Acommon in complete genomicsGood
- A;Cslight (~1.5x) increase in colorectal cancer riskBad
- C;Cslight (~2x) increase in colorectal cancer riskBad
rs16973225LOC102724001Worth knowing
- A;Acommon/normal; aspirin use reduces colorectal cancer risk a bitGood
- A;Cno reduction in colorectal cancer risk from taking aspirinBad
- C;Cno reduction in colorectal cancer risk from taking aspirinBad
rs1801274FCGR2AMinor
- G;Gnormal risk for cancer progressionGood
- A;Gcomplex; generally greater risk for cancer progressionBad
- A;Acomplex; generally greater risk for cancer progressionBad
rs4939827SMAD7Minor
- C;C0.73x decreased risk for colorectal cancerGood
- C;T0.86x decreased risk for colorectal cancerGood
- T;T1x risk for colorectal cancerBad
rs3834129CASP8Minor
- -;CTTACTSlightly decreased risk (0.9x) of certain cancersGood
- CTTACT;CTTACTcommon/normalGood
rs5275PTGS2Typical
- G;G0.68x decreased risk for bladder cancerGood
- A;G0.68x decreased risk for bladder cancerGood
- A;AnormalBad
rs396991FCGR3ATypical
- C;CnormalNot rated
- A;Ccomplex; generally greater risk for cancer progressionNot rated
- A;Acomplex; generally greater risk for cancer progressionGood
rs719725Typical
- A;A1.46x increased risk for colorectal cancerNot rated
- A;C1.5x increased risk for colorectal cancerNot rated
- C;CnormalNot rated
rs1047972AURKATypical
- C;Ccommon/normalGood
rs1049174KLRC4-KLRK1Typical
- G;GnormalNot rated
- C;G0.77x reduced risk for colorectal cancerNot rated
- C;C0.48x reduced risk for colorectal cancerNot rated
rs1800734MLH1Typical
- G;Gcommon in clinvarGood
rs1801278IRS1Typical
- T;Treduced colorectal risk when combined with INSR SNPNot rated
- C;Treduced colorectal risk when combined with INSR SNPNot rated
- C;CnormalGood
rs2306536CHFRTypical
- C;CaverageNot rated
- C;T?Not rated
- T;T0.5x lower risk of colorectal cancerNot rated
rs2308327MGMTTypical
- A;AnormalBad
- A;G0.67x decreased risk for lung cancerGood
- G;G0.10x decreased risk for lung cancerGood
rs2617170KLRC4Typical
- C;CNormalGood
rs4648261PTGS2Typical
- C;Ccommon in complete genomicsGood
rs12953717SMAD7Typical
- C;C1.37x increased risk for colorectal cancerNot rated
- C;T1.11x increased risk for colorectal cancerNot rated
- T;T1x normal risk for colorectal cancerBad
rs34815109UGT1A10Typical
- -;-normalNot rated
- -;TAsome effects of higher bilirubinNot rated
- TA;TAeffects of higher bilirubin; irinotecan toxicity; tranilast toxicityNot rated
rs116162724POLEVery important
- C;Ccommon/normalGood
- C;THigh risk of colorectal cancerBad
rs138207610POLEVery important
- A;GHigh risk of colorectal cancerBad
- G;Gcommon/normalGood
rs143340270POLD1Very important
- G;THigh risk of colorectal cancer; endometrial cancer risk also elevatedBad
- T;Tcommon/normalGood
rs143690372POLEVery important
- C;THigh risk of colorectal cancerBad
- T;Tcommon/normalGood
rs146530638POLD1Very important
- A;GHigh risk of colorectal cancer; endometrial cancer risk also elevatedBad
- G;Gcommon/normalGood
rs199700312POLD1Very important
- A;GHigh risk of colorectal cancer; endometrial cancer risk also elevatedBad
- G;Gcommon/normalGood
rs200403177POLEVery important
- A;GHigh risk of colorectal cancerBad
- G;Gcommon/normalGood
rs201010746POLD1Very important
- C;Ccommon/normalGood
- C;THigh risk of colorectal cancer; endometrial cancer risk also elevatedBad
rs201038430POLD1Very important
- A;GHigh risk of colorectal cancer; endometrial cancer risk also elevatedBad
- G;Gcommon/normalGood
rs201212113POLD1Very important
- A;Acommon/normalGood
- A;GHigh risk of colorectal cancer; endometrial cancer risk also elevatedBad
rs201503929POLD1Very important
- A;GHigh risk of colorectal cancer; endometrial cancer risk also elevatedBad
- G;Gcommon/normalGood
rs397514632POLD1Very important
- A;GSignificantly higher risk for colorectal and endometrial cancerBad
- G;Gcommon/normalGood
rs397514633POLD1Very important
- C;Ccommon/normalGood
- C;THigh risk of colorectal cancer; endometrial cancer risk also elevatedBad
rs869312753APCVery important
- C;Ccommon/normalGood
- C;TFamilial Adenomatous PolyposisBad
- T;Trisk factor for colorectal cancer?Bad
rs28939383PKHD1Very important
- G;GNo summary available.Not rated
- A;Gcarrier of a polycystic kidney disease alleleBad
- A;APolycystic kidney diseaseBad
rs121434492IL12RB1Very important
- G;Gcommon in complete genomicsGood
- A;GColorectal cancer risk increaseBad
- A;AImmunodeficiency (reported); IL12RB1 deficiencyBad
rs587779344PMS2Very important
- -;GLynch Syndrome (possible); high colorectal cancer riskBad
- G;Gcommon in clinvarGood
rs77542170MUTYHVery important
- C;Cautosomal recessive familial adenomatous polyposis-2 (FAP2)Bad
- C;TCarrier of a colorectal polyposis mutationBad
- T;Tcommon in clinvarGood
rs774277300MRE11AVery important
- C;CHereditary cancer predisposition (reported)Bad
- C;TColorectal cancer risk increaseBad
- G;Gcommon in clinvarGood
rs7861779RXRAWorth knowing
- T;TNo summary available.Not rated
rs16906252MGMTWorth knowing
- T;TNo summary available.Not rated
- G;GNo summary available.Not rated
- C;Ccommon/normalGood
rs58920878SMAD7Worth knowing
- C;Ccommon/normalGood
- C;Gslight (~1.5x) increase in colorectal cancer riskBad
- G;Gslight (~2x) increase in colorectal cancer riskBad

Genes

POLD110
POLE5
SMAD74
APC3
MUTYH3
AURKA2
DRD22
MGMT2
PTGS22
ADIPOQ1
ANKK11
CASC81

Genosets

Gs298Increased surveillance for colorectal cancer recommendedWorth knowing

Genosets combine several genotypes. Twofold checks them in your report.

Other SNPs

No notable genotype or detailed notes

Show 20 SNPs

rs481775
rs529359
rs863221
rs961253
rs964293
rs1864010
rs1982526
rs2617160
rs2617171
rs2665802
rs4444235
rs7014346
rs9929218
rs10505477
rs10795668
rs12654264
rs34743033
rs372833507
rs756198077
rs758673417

Source and license

Adapted from Colorectal cancer on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.