rs58920878

A SNP in the SMAD7 gene on chromosome 18. Its most notable genotype is C;G: slight (~1.5x) increase in colorectal cancer risk

Gene
SMAD7
Location
Chr 1848,923,195 (GRCh38)
Highest magnitude
2.0Worth knowing
Tested on
23andMe
Minor allele frequency
34%

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CGoodcommon/normalTypical · 0.0
  2. C;GMost notableBadslight (~1.5x) increase in colorectal cancer riskWorth knowing · 2.0
  3. G;GBadslight (~2x) increase in colorectal cancer riskWorth knowing · 2.0

On SNPedia: (C;C), (C;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other SMAD7 SNPs

All SMAD7 SNPs

Genosets

Genosets combine several genotypes. Twofold checks them in your report.

Notes

From SNPedia

Notes

rs58920878 on 18q21.1 (colorectal cancer OR 1.49, CI: 1.14–1.95, P=0.0035)

C;G

see discussion at rs58920878

G;G

see discussion at rs58920878

Source and license

Adapted from rs58920878 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.