rs774277300

A SNP in the MRE11A gene on chromosome 11. Its most notable genotype is C;C: Hereditary cancer predisposition (reported)

Gene
MRE11A
Location
Chr 1194,447,276 (GRCh38)
Highest magnitude
5.0Very important
Tested on
AncestryDNA

Genotypes

As shown in 23andMe and AncestryDNA files.

  1. C;CMost notableBadHereditary cancer predisposition (reported)Very important · 5.0
  2. C;TBadColorectal cancer risk increaseVery important · 5.0
  3. G;GGoodcommon in clinvarTypical · 0.0

On SNPedia: (C;C), (C;T), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.

Conditions, medicines and genes

Other MRE11A SNPs

All MRE11A SNPs

Notes

From SNPedia

Notes

rs774277300, also known as c.1726C>T and p.Arg576Ter, represents a rare mutation in the MRE11A gene on chromosome 11. Inherited dominantly, the minor allele is reported to increase risk for colorectal cancer. Separately, a different allele for this SNP, c.1726C>G (p.Arg576Gly), is reported in ClinVar as pathogenic for a hereditary cancer-predisposing syndrome.

C;C

see rs774277300

C;T

see rs774277300

Source and license

Adapted from rs774277300 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.

SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.