rs34612342
A SNP in the MUTYH gene on chromosome 1. Its most notable genotype is C;C: increased risk for several cancers
- Gene
- MUTYH
- Location
- Chr 145,332,803 (GRCh38)
- Highest magnitude
- 5.0Very important
- Tested on
- 23andMe, AncestryDNA
Genotypes
Plus strand, as in 23andMe and AncestryDNA files.
- T;TGoodcommon in clinvar
- C;TBadincreased risk for several cancers
- C;CMost notableBadincreased risk for several cancers
SNPedia records rs34612342 on the minus strand: (A;A), (A;G), (G;G). Magnitude rates how notable a genotype is from 0 to 10, not how risky it is.
Related
Conditions, medicines and genes
Other MUTYH SNPs
- rs36053993T;Tlikely to be at somewhat increased risk for colorectal cancersVery important
- rs77542170C;Cautosomal recessive familial adenomatous polyposis-2 (FAP2)Very important
- rs200165598C;TPossible polyp associated variant, but of uncertain significanceVery important
- rs1060501342-;CCincreased risk for several cancersVery important
- rs121908380G;TCarrier of a MUTYH-related familial adenomatous polyposis mutationImportant
- rs121908381A;CCarrier of a MUTYH-related familial adenomatous polyposis mutationImportant
- rs143353451C;TCarrier of a MUTYH-related familial adenomatous polyposis mutationImportant
- rs376561094A;GCarrier of a MUTYH-related familial adenomatous polyposis mutationImportant
Genosets
Genosets combine several genotypes. Twofold checks them in your report.
Notes
From SNPedia
Show notes, about 170 words
rs34612342, also known as c.536A>G, Tyr179Cys and Y179C, is one of the two most common pathogenic mutations in the MUTYH gene in patients of European origin. The normal allele, encoding the tyrosine, is rs34612342(A), while rs34612342(G) is the risk allele. [Mutation nomenclature according to Genbank accession number NM_001128425.1 c.536A>G, p.Tyr179Cys; alternative numbering can lead to this SNP also being called Tyr151Cys, Tyr152Cys, Tyr165Cys, or Tyr176Cys.] Both rs34612342 and rs36053993 are considered founder mutations that first arose in ancestors who lived between 5–8 thousand years and 6–9 thousand years B.C., respectively. Germline bi-allelic mutations in the MUTYH gene increase the risk of developing multiple adenomatous polyps and colorectal cancer.
C;T
Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer
C;C
Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer
References
Source and license
Adapted from rs34612342 on SNPedia, using a snapshot taken October 16, 2026. SNPedia content is shared under CC BY-NC-SA 3.0 US, and this page is shared under the same license.
SNPedia is a community-edited wiki. Its entries can be incomplete, out of date or wrong, and nothing here is a diagnosis or medical advice. Magnitude is a community rating of how interesting a genotype is, not a risk score.